Human Biospecimens can find usage in several application:

High quality DNA, RNA & proteins samples from various tissue specimens are required for investigating genotype, loss of heterozygosity, mutation analyses and other applications. Molecular isolation and testing services offered by YBL.

Figure 1: Representative PCR data images of tumor tissue biopsy exhibit BRCA1, BRCA2, PR and Her2 mutations.

Human biological fluids and tissues, procured through expeditious cold-chain and maintained in temperature-controlled environment (low-traffic, non-pooled aliquots) are useful in biomarker research.
Primary cells (i.e. PBMCs) are useful in iPSCs technology, T cell engineering, immune cells research etc. cell engineering, cell-line development and immunophenotyping assays and services offered by YBL.

Figure 2: Representative images induced pluripotent stem cells (iPSCs) developed in YBL using healthy and diseased donor somatic cells.

Normal and Diseased Organoids (e.g. Healthy Tissue and Breast/Ovarian Cancer etc. Tissue Organoids) for in vitro high-throughput preclinical drug testing.

Figure 3: Representative immunostaining images of Grade III Metastatic breast cancer biopsy organoid showing expression of Breast Cancer Marker-Her2 (orange), Proliferation Marker-Ki67 (green) and cell nuclei (blue) developed in YBL

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Figure 4: Representative immunostaining images of Mucinous Adenocarcinoma with reactive nodes in ovary cancer biopsy organoid showing expression of endothelial cell marker CD31 (orange), Ovarian Cancer marker-HE4 (green) and cell nuclei (blue) developed in YBL

Figure 5: Representative immunostaining images of Normal tissue biopsy organoid showing expression of endothelial cell marker CD31 (orange), Proliferation Marker-Ki67 (green) and cell nuclei (blue) developed in YBL

Primary cancer cells/platforms available through YBL can be used for In vivo Preclinical Drug Testing using Xenograft Model Development services (offered by YBL).

Figure 6: Representative immunostaining images of Patient-derived xenograft (PDX) showing expression of liver marker AFP (green) and cell nuclei (blue) developed in YBL

Primary human tissue and bio-fluids can be used for biomarker screening and testing

(services offered by YBL).