This conference poster presents an advanced microfluidic co-culture platform that reconstructs neurocutaneous interactions using human iPSC-derived sensory neurons and melanocytes. The study demonstrates how controlled neuron-melanocyte crosstalk can be modeled in vitro to better understand melanogenic signaling pathways and the biological mechanisms underlying neurocutaneous toxicology.

Using a compartmentalized DUALINK microfluidic system, the study showed that sensory neurite-dependent interactions influence melanocyte activity and pigmentation-related pathways. This platform offers strong potential as a physiologically relevant in vitro model for evaluating neurocutaneous toxic effects, drug-induced pigment loss, and skin-related therapeutic screening.