Human iPSC Models at the Nexus of Environmental Exposures and Human Health

Human iPSC Models at the Nexus of Environmental Exposures and Human Health: Advancements, Applications, and Future Directions

Summary

Researchers at Yashraj Biotechnology Ltd. review the growing role of human induced pluripotent stem cells (iPSCs) in environmental toxicology, synthesizing recent advances (2022–2025) in AI integration, multi-omics profiling, and the emerging "digital twin" concept for personalized risk assessment.

The review covers iPSC-derived models across hepatic, neural, cardiac, pulmonary, and renal systems, examining their response to toxicants like heavy metals, PFAS, and microplastics, and compares their advantages and limitations against animal models, primary cells, and immortalized cell lines.

It concludes by outlining the current regulatory landscape and key research priorities — immune integration, organ-on-chip development, and chronic exposure modeling — needed to advance regulatory acceptance of iPSC-based methods in environmental health